PH12404

货号 规格 价格(¥)
PH12404S 50ul
PH12404M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-IPAB Antibody

Datasheet

Background

Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells . IpaB/SctE and IpaC/SctB are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells . Interaction with IpaD/SctA at needle tips leads to the formation of the MxiH/SctF-IpaD/SctA-IpaB/SctE ternary complex, which is essential for host cell sensing . Interaction of IpaB/SctE with host membrane lipids promotes recruitment of IpaC/SctB at the needle tip concomitant with translocon insertion into the host membrane and type III secretion induction . .; Required for efficient dissemination . Necessary for lysis of the two cellular membranes that surround bacteria in protrusions during cell-to-cell spread . Is sufficient to induce macrophage apoptosis through activation of the interleukin-1 beta converting enzyme (ICE) in infected macrophages . In epithelial cells, causes cell-cycle arrest by targeting host MAD2L2, an anaphase-promoting complex/cyclosome (APC) inhibitor . .

Alternative Name

Type 3 secretion system translocon protein SctE (T3SS translocon protein SctE) (62 kDa antigen) (Invasin IpaB) sctE ipaB CP0128

Reactivity

Shigella flexneri

Predicted Reactivity

Application

WB,ELISA

Application Image

Recommended Dilution

WB 1:1000-1:2000
ELISA 1:5000-1:20000

Mol Weight

62kD

Gene Symbol

sctE ipaB CP0128

Uniprot

p18011

Uniprot link

Immunogen

Recombinant Shigella flexneri IPAB protein (1-312aa)

Immunogen Range

Source

Rabbit

Clonality

Polyclonal

Isotype

IgG

Specificity

Subcellular location

Research Area

Positive control

Conjugation

Modification

Purification

Protein G

Formulation

Liquid

Concentration

1mg/ml

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

产品介绍

Clone

Target

波长

Storage

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.

注意事项

Companion Products

Important

Comments

RRID

客户评价

艾比玛特医药科技(上海)有限公司
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技术支持:15618194176(微信同号)

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华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

46c73bc4c7a4d51a3ce472aedb80205b_compress.jpg

      微信客服

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