Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is the only viral peptide matured by host furin in the trans-Golgi network probably to avoid catastrophic activation of the viral fusion activity in acidic Golgi compartment prior to virion release. prM-E cleavage is inefficient, and many virions are only partially matured. These uncleaved prM would play a role in immune evasion. .; Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host alpha/beta interferon antiviral response. .; Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter. .; Inhibits RNA silencing by interfering with host Dicer. .; Involved in immune evasion, pathogenesis and viral replication. Once cleaved off the polyprotein, is targeted to three destinations: the viral replication cycle, the plasma membrane and the extracellular compartment. Essential for viral replication. Required for formation of the replication complex and recruitment of other non-structural proteins to the ER-derived membrane structures. Excreted as a hexameric lipoparticle that plays a role against host immune response. Antagonizing the complement function. Binds to the host macrophages and dendritic cells. Inhibits signal transduction originating from Toll-like receptor 3 (TLR3). .; May play a role in virus budding. Exerts cytotoxic effects by activating a mitochondrial apoptotic pathway through M ectodomain. May display a viroporin activity. .; Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions. Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway. .

Genome polyprotein

Japanese encephalitis virus

WB,ELISA

WB 1:1000-1:2000
ELISA 1:5000-1:20000

380kD

q99dq9

Recombinant Japanese encephalitis virus Genome polyprotein,partial (2780-3428aa)

Rabbit

Polyclonal

IgG

Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Fusion of virus membrane with host endosomal membrane #Inhibition of host interferon signaling pathway by virus #Virus entry into host cell #Viral RNA replication #Viral attachment to host cell #proteolysis,

Protein G

Liquid

1mg/ml

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.