13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
alternative products:Additional isoforms seem to exist|Catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.|cofactor:Binds 1 zinc ion per subunit.|cofactor:Calcium.|disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Strongly inhibited by TIMP-2| TIMP-3 and TIMP-4| while TIMP-1 is less efficient.|Endopeptidase that degrades various components of the extracellular matrix| such as aggrecan and cartilage oligomeric matrix protein (comp)| during development| haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV| laminin| nidogen| nascin-C isoform| fibronectin| and type I gelatin.|PTM:Activated by autolytic cleavage after Lys-97.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|tissue specificity:Expressed in mammary gland| placenta| lung| pancreas| ovary| small intestine| spleen| thymus| prostate| testis colon| heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.|
Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18) MMP19 MMP18 RASI
Human, Mouse
WB,ELISA
WB 1:500-2000ELISA 1:10000-50000
57kD
MMP19 MMP18 RASI
human: q99542; mouse: q9jhi0
Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)
Rabbit
Polyclonal
IgG
Cancer; Cardiovascular; Cell biology; Signal transduction
Liquid
1mg/ml
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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徐经理：手机15618191473（微信同号）
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