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Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Human AKT serine-threonine protein kinase family includes three members AKT1,AKT2, AKT3, which are also often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene.
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) AKT1 PKB RAC
Human,Mouse,Rat
WB,IHC,IF,ICC,IP
WB 1:500-1000IHC 1:50-200IF 1:50-100ICC 1:100-1:400IP 0.5μg-4μg
48/55/51/54kDa
207/208/10000
p31749/p31751/q9y243
Recombinant protein of human AKT1/AKT2/AKT3
Rabbit
Polyclonal Antibody
IgG
ciliary basal body,cytoplasm,cytosol,microtubule cytoskeleton,mitochondrion,nucleoplasm,nucleus,plasma membrane,spindle
Sugar transport #Differentiation
Affinity purification
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
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程经理：手机18616261485（微信同号）
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