13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation. Tuberin is phosphorylated on Ser939 and Thr1462 in response to PI3K activation and that the human TSC complex is a direct biochemical target of the PI3K/Akt pathway. This data complements Drosophila genetics studies suggesting the possible involvement of the tuberin-hamartin complex in the PI3K/Akt mediated insulin pathway.
FLJ43106 antibody
LAM antibody
OTTHUMP00000158940 antibody
OTTHUMP00000198394 antibody
OTTHUMP00000198395 antibody
PPP1R160 antibody
Protein phosphatase 1, regulatory subunit 160 antibody
TSC complex subunit 2 antibody
tsc2 antibody
TSC2_HUMAN antibody
TSC4 antibody
TSC4 gene, formerly antibody
TSC4, formerly antibody
Tuberin antibody
Tuberous sclerosis 2 antibody
Tuberous sclerosis 2 protein antibody
Tuberous sclerosis 2 protein homolog antibody
Human,Mouse,Rat
WB
WB 1:1000
Predicted band size: 201 kDa
TSC2, TSC4
p49815>swissprot: p49815 human;swissprot: q61037 mouse;swissprot: p49816 rat
Rabbit
Recombinant Rabbit monoclonal Antibody
IgG
Cytoplasm, Membrane.
Cell Biology->Cell Cycle;Signal Transduction->Protein Trafficking;Signal Transduction->Protein Trafficking->Vesicle Transport->Regulation;Epigenetics and Nuclear Signaling->Transcription->Cancer susceptibility->Tumor Suppressors;Metabolism->Obesity;Neuroscience->Neurodevelopmental disorders: ASD
SH-SY5Y treated with 200nM Calyculin A and 1μM Okadaic Acid for 1 hour cell lysate.
Protein A affinity purified.
Liquid
1 mg/mL.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
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微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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