This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.

70 kDa ribosomal protein S6 kinase 1 antibody
p70 alpha antibody
p70 S6 kinase alpha antibody
p70 S6K antibody
p70 S6KA antibody
p70(S6K) alpha antibody
p70s6kA antibody
PS6K antibody
Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody
ribosomal protein S6 kinase beta 1 antibody
ribosomal protein S6 kinase I antibody
Ribosomal protein S6 kinase, 70-kD antibody
RPS6KB1 antibody
S6K antibody
S6K1 antibody
Serine/threonine kinase 14 alpha antibody
Serine/threonine protein kinase 14A antibody
STK14A antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000-1:2000
IHC 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 59 kDa

RPS6KB1, STK14A

p23443>swissprot: p23443 human;swissprot: q8bsk8 mouse;entrez gene: 83840 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Synapse, synaptosome, Mitochondrion outer membrane, Mitochondrion.

Cell Biology->Cell Cycle;Cancer->Signal transduction;Signal Transduction->Protein Phosphorylation;Epigenetics and Nuclear Signaling->DNA / RNA;Metabolism->lipid and Glucose metabolism;Metabolism->Metabolic disorders;Metabolism->Obesity;Metabolism->Diabetes;Neuroscience->Neurodevelopmental disorders: ASD

MCF7 cell lysate, MCF7 treated with 20% FBS overnight then add 100nM Calyculin A for 30 minutes cell lysate, NIH/3T3 treated with 20% FBS overnight then add 100nM Calyculin A for 30 minutes cell lysate, human breast carcinoma tissue, MCF7 starved for 4 hours then treated with 200ng/mL EGF for 15 minutes cell lysate, C6 cell lysate, C6 treated with 100nM Calyculin A for 30 minutes cell lysate, human liver carcinoma tissue, 293T cell lysate, 293T serum starved overnight cell lysate, 293T serum starved overnight then treated with 100nM Insulin for 15 minutes cell lysate, MCF7 cells treated with 20% FBS overnight then add 100nM Calyculin A for 30 minutes.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.