HER-2 (also called HER-2/neu, c-erbB2, ERBB2 or neu) is a transmembrane receptor tyrosine kinase. HER-2 is a proto-oncogene, i.e. its activation causes malignant transformation and increases the malignant potential (cell proliferation, invasiveness etc.) of the cells. Amplification of HER-2 gene invariably leads to over-expression of its protein product. The magnitude of over- expression is usually 10-100 folds or even more. Over-expressed HER-2 protein disturbs the HER-receptor family signalling networks, i.e. signalling mediated via EGFR receptor, HER-3 and HER-4. In tumours, HER-2 is over-expressed in 15-25% of primary breast cancers. Metastases usually have the same amplification status as the primary tumours. HER-2 amplification and over-expression are typical features of hormone receptor negative, rapidly growing histologic grade 2-3 tumours. Of the histologic types, Paget’s disease is almost invariably HER-2 positive, whereas only a small minority of lobular and tubular carcinomas shows HER-2 amplification. HER-2 amplification and over-expression can also be found in intestinal type gastric and gastroesophageal carcinomas, ovarian carcinomas, high grade endometrial carcinomas and some salivary duct tumours. Low-level copy number increases have been found also in rare cases of lung tumours. Because of its central importance in breast cancer therapy selection, standardization of HER-2 IHC assays and slide interpretation are of outmost clinical and economical importance.

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
C erb B2/neu protein antibody
CD340 antibody
CD340 antigen antibody
Cerb B2/neu protein antibody
CerbB2 antibody
Erb b2 receptor tyrosine kinase 2 antibody
ErbB-2 proto-oncogene antibody
ERBB2 antibody
ERBB2_HUMAN antibody
HER 2 antibody
HER 2/NEU antibody
HER2 antibody
Herstatin antibody
Human epidermal growth factor receptor 2 antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
MLN19 antibody
NEU antibody
NEU proto oncogene antibody
Neuro/glioblastoma derived oncogene homolog antibody
Neuroblastoma/glioblastoma derived oncogene homolog antibody
NGL antibody
p185erbB2 antibody
Proto-oncogene c-ErbB-2 antibody
Proto-oncogene Neu antibody
Receptor tyrosine-protein kinase erbB-2 antibody
TKR1 antibody
Tyrosine kinase type cell surface receptor HER2 antibody
Tyrosine kinase-type cell surface receptor HER2 antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody
V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

Human

WB,IF,ICC

WB 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 138 kDa

ERBB2, HER2, MLN19, NEU, NGL

p04626>swissprot: p04626 human

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cell membrane, Cell projection, ruffle membrane; Early endosome, Cytoplasm, perinuclear region, Nucleus.

Cancer->Cancer Biomarker;Cancer->Tumor immunology;Cancer->Tumor immunology->Tumor-associated antigens;Cancer->Growth factors;Cancer->Growth factors->EGF;Signal Transduction->Protein Phosphorylation;Signal Transduction->Protein Phosphorylation->Ser / Thr Kinases->Other Kinases;Signal Transduction->Protein Phosphorylation->Tyrosine Kinases->Receptor Tyrosine Kinases;Signal Transduction->Growth Factors/Hormones;Signal Transduction->Growth Factors/Hormones->EGF;Epigenetics and Nuclear Signaling->ChIP assays;Epigenetics and Nuclear Signaling->ChIP assays->ChIP kits

SK-Br-3 cell lysate, SK-Br-3 starved for 4 hours add 200ng/mL EGF for 15 minutes cell lysate, HeLa starved for 4 hours add 200ng/mL EGF for 15 minutes cell lysate, HeLa cells starved for 4 hours add 200ng/mL EGF for 15 minutes.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.