Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene. Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an N-terminal EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a proline-rich region that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Vasodilator stimulated phosphoprotein antibody
Vasodilator-stimulated phosphoprotein antibody
VASP antibody
VASP_HUMAN antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000
IHC 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 40 kDa

VASP

p50552>swissprot: p50552 human;swissprot: p70460 mouse;entrez gene: 361517 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, cytoskeleton, Cell junction, focal adhesion, tight junction, Cell projection, lamellipodium membrane, filopodium membrane.

Signal Transduction->Cytoskeleton / ECM;Signal Transduction->Cytoskeleton / ECM->Extracellular Matrix->Structures->Focal Adhesions;Metabolism->lipid and Glucose metabolism

HeLa treated with 100ng/mL Calyculin A for 30 minutes cell lysate, NIH/3T3 treated with 100nM Calyculin A for 30 minutes cell lysate, A431 cells treated with 10μM forskolin for 1 hour, mouse spleen tissue, rat spleen tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.