The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

c erbB 3 antibody
c erbB3 antibody
Erb b2 receptor tyrosine kinase 3 antibody
ErbB 3 antibody
ERBB3 antibody
ERBB3 protein antibody
erbB3 S antibody
ERBB3_HUMAN antibody
Glial growth factor receptor antibody
HER 3 antibody
HER3 antibody
Human epidermal growth factor receptor 3 antibody
LCCS2 antibody
MDA BF 1 antibody
MGC88033 antibody
p180 ErbB3 antibody
p45 sErbB3 antibody
p85 sErbB3 antibody
proto-oncogene-like protein c ErbB 3 antibody
proto-oncogene-like protein c ErbB3 antibody
Proto-oncogene-like protein c-ErbB-3 antibody
Receptor tyrosine protein kinase erbB 3 antibody
Receptor tyrosine protein kinase erbB3 antibody
Receptor tyrosine-protein kinase erbB-3 antibody
Tyrosine kinase type cell surface receptor HER3 antibody
Tyrosine kinase-type cell surface receptor HER3 antibody
v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

Human

WB,IF,ICC

WB 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 148 kDa

ERBB3

p21860>swissprot: p21860 human

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cell membrane, secreted.

Cancer->Growth factors->EGF;Signal Transduction->Protein Phosphorylation;Signal Transduction->Protein Phosphorylation->Tyrosine Kinases->Receptor Tyrosine Kinases;Signal Transduction->Growth Factors/Hormones;Signal Transduction->Growth Factors/Hormones->EGF

MCF7 serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes cell lysate, MCF7 cells serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.