13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. This kinase has also been shown to regulate downstream cytokine expression such as TNF. Due to its regulation of TNF, TAK1 has become a novel target for the treatment of TNF mediated diseases such as auto immune disease ( Rheumatoid Arthritis, lupus, IBD) but also other cytokine mediated disorders such as chronic pain and cancer. With the advent of novel selective TAK1 inhibitors, groups have explored the therapeutic potential of TAK1 targeted therapies. One group has shown that the selective TAK1 inhibitor, Takinib developed at Duke University attenuated rheumatoid arthritis like pathology in the CIA mouse model of human inflammatory arthritis. Furthermore, pharmacological inhibition of TAK1 has shown to reduce inflammatory cytokines in particular TNF.
M3K7_HUMAN antibody
MAP3K 7 antibody
Map3k7 antibody
MEKK7 antibody
Mitogen activated protein kinase kinase kinase 7 antibody
Mitogen-activated protein kinase kinase kinase 7 antibody
TAK1 antibody
TGF beta activated kinase 1 antibody
TGF-beta-activated kinase 1 antibody
TGF1a antibody
Transforming growth factor beta activated kinase 1 antibody
Transforming growth factor-beta-activated kinase 1 antibody
Human,Mouse,Rat
WB
WB 1:5000-1:25000
Predicted band size: 67 kDa
MAP3K7, TAK1
o43318>swissprot: o43318 human;swissprot: q62073 mouse;swissprot: p0c8e4 rat
Rabbit
Recombinant Rabbit monoclonal Antibody
IgG
Cytoplasm, Cell membrane.
Immunology->Innate Immunity->TLR Signaling;Cancer->Signal transduction->Protein phosphorylation->Serine/threonine kinases->MAPK pathway;Cancer->Cell Death->Necroptosis;Signal Transduction->Protein Phosphorylation->Ser / Thr Kinases->MAPK Pathway;Signal Transduction->Protein Phosphorylation->Tyrosine Kinases->Receptor Tyrosine Kinases;Cardiovascular->Atherosclerosis->Vascular Inflammation->Inflammatory mediators
HeLa cell lysate, HeLa treated with 100ng/mL Calyculin A for 30 minutes cell lysate, NIH/3T3 cell lysate, NIH/3T3 treated with 100nM Calyculin A for 30 minutes cell lysate, PC-12 cell lysate, PC-12 treated with 100nM Calyculin A for 30 minutes cell lysate.
Protein A affinity purified.
Liquid
1 mg/mL.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
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微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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