Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes. Protein kinase C-alpha (PKC-α) is a specific member of the protein kinase family. These enzymes are characterized by their ability to add a phosphate group to other proteins, thus changing their function. PKC-α has been widely studied in the tissues of many organisms including drosophila, xenopus, cow, dog, chicken, human, monkey, mouse, pig, and rabbit. Many studies are currently being conducted investigating the structure, function, and regulation of this enzyme. The most recent investigations concerning this enzyme include its general regulation, hepatic function, and cardiac function.

AAG6 antibody
Aging associated gene 6 antibody
aPKC antibody
KPCA_HUMAN antibody
PKC alpha antibody
PKC-A antibody
PKC-alpha antibody
PKCA antibody
PRKACA antibody
PRKCA antibody
Protein Kinase C alpha antibody
Protein kinase C alpha type antibody

Human,Mouse,Rat

WB,IF,ICC,FC

WB 1:2000
IF 1:100-1:400
ICC 1:100-1:3000
FC 1:1000

Predicted band size: 77 kDa

PRKCA, PKCA, PRKACA

p17252>swissprot: p17252 human;swissprot: p20444 mouse;swissprot: p05696 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Cell membrane, Mitochondrion membrane, Nucleus.

Signal Transduction->Protein Phosphorylation->Ser / Thr Kinases->PKC;Cardiovascular->Heart->Hypertrophy->Other;Epigenetics and Nuclear Signaling->Histones->H3->Methylated

HeLa cell lysate, NIH/3T3 cell lysate, C6 cell lysate, MCF7 cells treated with 100nM PMA for 1 hour, HeLa, K-562, NIH/3T3, C6.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.