TU22341

货号 规格 价格(¥)
TU22341S 50ul
TU22341M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   免疫荧光

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   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-FLAP Antibody

Datasheet

Background

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consists of 4 transmembrane alpha helices, but they are found in trimer forming a barrel. The barrel is about 60 high and 36 wide.

Alternative Name

5-lipoxygenase activating protein antibody
AL5AP_HUMAN antibody
ALOX 5AP antibody
ALOX5 AP antibody
ALOX5AP antibody
Arachidonate 5 lipoxygenase activating protein antibody
Arachidonate 5-lipoxygenase-activating protein antibody
Five lipoxygenase activating protein antibody
FLAP antibody
MK 886 binding protein antibody
MK-886-binding protein antibody

Reactivity

Human

Application

WB

Recommended Dilution

WB 1:1000

Application Image

Mol Weight

Predicted band size: 18 kDa

Gene Symbol

ALOX5AP, FLAP

Uniprot

p20292>swissprot: p20292 human

Uniprot link

Immunogen

Immunogen Range

Source

Rabbit

Clonality

Recombinant Rabbit monoclonal Antibody

Isotype

IgG

Specificity

Subcellular location

Nucleus membrane, Endoplasmic reticulum membrane.

Research Area

Immunology->Immune System Diseases->Allergens;Immunology->Innate Immunity->Macrophage / Inflamm;Signal Transduction->Second Messenger->Lipid Messengers;Cardiovascular->Atherosclerosis->Vascular Inflammation->Inflammatory mediators

Positive control

U-937 cell lysate, THP-1 cell lysate, THP-1 treated with 50nM TPA overnight then add 5μg/mL LPS for 8 hours cell lysate.

Conjugation

Modification

Purification

Protein A affinity purified.

Formulation

Liquid

Concentration

1 mg/mL.

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

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华南经销商负责(广东,广西,福建,海南):
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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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