The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation . ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation.

Villin 2 ezrin antibody
CVIL antibody
CVL antibody
Cytovillin 2 antibody
Cytovillin antibody
DKFZp762H157 antibody
Epididymis secretory protein Li 105 antibody
EZR antibody
EZRI_HUMAN antibody
Ezrin antibody
FLJ26216 antibody
HEL S 105 antibody
MGC1584 antibody
p81 antibody
VIL 2 antibody
VIL2 antibody
Villin 2 (ezrin) antibody
Villin 2 antibody
Villin-2 antibody
Villin2 antibody
CB567 antibody
CG12537 antibody
DFNB24 antibody
ESP10 antibody
Hh-induced MATH and BTB domain-containing protein antibody
HIB antibody
Moesin-B antibody
Protein roadkill antibody
RADI_HUMAN antibody
Radixin antibody
RDX antibody
Epididymis luminal protein 70 antibody
HEL70 antibody
Membrane organizing extension spike protein antibody
Membrane-organizing extension spike protein antibody
MOES_HUMAN antibody
Moesin antibody
Moesin/anaplastic lymphoma kinase fusion protein antibody
Msn antibody
MSN/ALK fusion antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:2000
IHC 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 69 kDa

Ezrin
Cytovillin
Villin-2
p81
EZR
VIL2
Radixin
RDX
Moesin
Membrane-organizing extension spike protein
MSN

p15311>swissprot: p15311 human;swissprot: p26038 human;swissprot: p35241 human;swissprot: p26040 mouse;swissprot: p26041 mouse;swissprot: p26043 mouse;swissprot: p31977 rat;swissprot: o35763 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cell membrane. Cell projection. Cytoplasm. Cytoskeleton. Membrane

Cancer->Signal transduction->Protein phosphorylation->Other;Signal Transduction->Cytoskeleton / ECM->Cytoskeleton->Microfilaments->Actin etc->Actin Binding Proteins;Signal Transduction->Cytoskeleton / ECM->Cytoskeleton->Microfilaments->Actin etc->Actin;Signal Transduction->Adapters->Cytoplasmic

HeLa starved for 3 hours then add 100nM Calyculin A for 30 minutes cell lysate, NIH/3T3 starved for 24 hours then add 100nM Calyculin A for 30 minutes cell lysate, C6 treated with 100ng/mL Calyculin A for 1 hours cell lysate, mouse liver tissue, rat liver tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.