Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53.

CVID9 antibody
D14Ertd420e antibody
Kinase PKC delta antibody
KPCD antibody
KPCD_HUMAN antibody
MAY 1 antibody
MAY1 antibody
MGC49908 antibody
nPKC delta antibody
nPKC-delta antibody
PCKd antibody
PKC d antibody
PKC delta antibody
PKCD antibody
PKCdelta antibody
PRKC D antibody
PRKC delta antibody
Prkcd antibody
Protein Kinase C delta antibody
Protein kinase C delta type antibody
Protein kinase C delta VIII antibody
Protein Kinase Cdelta antibody
Tyrosine protein kinase PRKCD antibody

Human,Mouse,Rat

WB

WB 1:1000

Predicted band size: 78 kDa

Protein kinase C delta type
Tyrosine-protein kinase PRKCD
nPKC-delta
Protein kinase C delta type regulatory subunit
Protein kinase C delta type catalytic subunit Alternative names: Sphingosine-dependent protein kinase-1 (SDK1)
PRKCD
PKCD

q05655>swissprot: q05655 human;swissprot: p28867 mouse;swissprot: p09215 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cell membrane. Cytoplasm. Membrane. Mitochondrion. Nucleus.

Signal Transduction->Protein Phosphorylation->Ser / Thr Kinases->PKC

THP-1 cell lysate, THP-1 treated with 50ng/mL PMA for 72 hours cell lysate, THP-1 treated with 100ng/mL PMA for 72 hours cell lysate, mouse small intestine tissue lysate, rat lung tissue lysate.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.