TU22472

货号 规格 价格(¥)
TU22472S 50ul
TU22472M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

ABMART实验方案下载

   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

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   植物BPP法变性蛋白提取

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经典一抗-Phospho-p130 (T986) Antibody

Datasheet

Background

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Alternative Name

130 kDa retinoblastoma associated protein antibody
130 kDa retinoblastoma-associated protein antibody
IB4 antibody
p130 antibody
PPAR-alpha-interacting complex protein 128 antibody
PRB2 antibody
Rb2 antibody
Rbl2 antibody
RBL2_HUMAN antibody
RBR 2 antibody
RBR-2 antibody
RBR2 antibody
Retinoblastoma like 2 antibody
Retinoblastoma-like protein 2 antibody
Retinoblastoma-related protein 2 antibody
RIC128 antibody

Reactivity

Human,Mouse,Rat

Application

WB,IHC

Recommended Dilution

WB 1:1000
IHC 1:200

Application Image

Mol Weight

Predicted band size: 128 kDa

Gene Symbol

Retinoblastoma-like protein 2
130 kDa retinoblastoma-associated protein (p130)
Retinoblastoma-related protein 2 (RBR-2)
pRb2
RBL2
RB2

Uniprot

q08999>swissprot: q08999 human;swissprot: q64700 mouse;swissprot: o55081 rat

Uniprot link

Immunogen

Immunogen Range

Source

Rabbit

Clonality

Recombinant Rabbit monoclonal Antibody

Isotype

IgG

Specificity

Subcellular location

Nucleus.

Research Area

Cell Biology->Cell Cycle->Cell Division->Other cell division antibodies;Cell Biology->Cell Cycle->Cell Cycle Inhibitors->Rb;Cancer->Cell cycle->Cell cycle inhibitors->Rb;Epigenetics and Nuclear Signaling->Cell cycle->Cell Cycle Inhibitors->Rb

Positive control

Jurkat cell lysate, K-562 cell lysate, NIH/3T3 cell lysate, C2C12 cell lysate, PC-12 cell lysate, human appendix tissue, human colon cancer tissue, mouse colon tissue, rat colon tissue.

Conjugation

Modification

Purification

Protein A affinity purified.

Formulation

Liquid

Concentration

1 mg/mL.

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

艾比玛特医药科技(上海)有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

46c73bc4c7a4d51a3ce472aedb80205b_compress.jpg

      微信客服

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