This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape.

90 kDa nucleolus organizer region autoantigen antibody
Autoantigen NOR-90 antibody
NOR 90 antibody
Nucleolar transcription factor 1 antibody
UBF 1 antibody
UBF antibody
UBF-1 antibody
UBF1_HUMAN antibody
Ubtf antibody
Upstream binding factor 1 antibody
upstream binding transcription factor, RNA polymerase I antibody
Upstream-binding factor 1 antibody

Human,Mouse,Rat

WB,IHC

WB 1:1000
IHC 1:1000

Predicted band size: 89 kDa

Nucleolar transcription factor 1
Autoantigen NOR-90
Upstream-binding factor 1 (UBF-1)
UBTF
UBF, UBF1

p17480>swissprot: p17480 human;swissprot: p25976 mouse;swissprot: p25977 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Nucleus, nucleolus.

Epigenetics and Nuclear Signaling

HeLa cell lysate, HeLa treated with 100ng/mL Nocodazole for 18 hours cell lysate, human testis tissue, human breast cancer tissue, mouse testis tissue, rat testis tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.