FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids forming a motif that binds to DNA. This forkhead motif is also known as the winged helix, due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead proteins are a subgroup of the helix-turn-helix class of proteins. Some FOX genes are downstream targets of the hedgehog signaling pathway, which plays a role in the development of basal cell carcinomas. Members of class O (FOXO- proteins) regulate metabolism, cellular proliferation, stress tolerance and possibly lifespan. The activity of FoxO is controlled by post-translational modifications, including phosphorylation, acetylation and ubiquitination.

FKH 1 antibody
FKH1 antibody
FKHR antibody
Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody
Forkhead box O1 antibody
Forkhead box protein O1 antibody
Forkhead box protein O1A antibody
Forkhead in rhabdomyosarcoma antibody
Forkhead, Drosophila, homolog of, in rhabdomyosarcoma antibody
FoxO transcription factor antibody
foxo1 antibody
FOXO1_HUMAN antibody
FOXO1A antibody
OTTHUMP00000018301 antibody
AF6q21 antibody
AF6q21 protein antibody
DKFZp781A0677 antibody
FKHR2 antibody
FKHRL 1 antibody
FKHRL1 antibody
FKHRL1P2 antibody
Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody
Forkhead box O3 antibody
Forkhead box O3A antibody
Forkhead box protein O3 antibody
Forkhead box protein O3A antibody
Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody
Forkhead homolog (rhabdomyosarcoma) like 1 antibody
Forkhead in rhabdomyosarcoma like 1 antibody
Forkhead in rhabdomyosarcoma-like 1 antibody
FOX O3A antibody
FOXO2 antibody
foxo3 antibody
FOXO3_HUMAN antibody
FOXO3A antibody
MGC12739 antibody
MGC31925 antibody
AFX antibody
AFX1 antibody
Afxh antibody
ALL1-fused gene from X chromosome antibody
Fork head domain transcription factor AFX1 antibody
Forkhead box O4 antibody
Forkhead box protein O4 antibody
FOXO 4 antibody
Foxo4 antibody
FOXO4_HUMAN antibody
MGC117660 antibody
MGC120490 antibody
Mixed lineage leukemia, translocated to, 7 antibody
MLLT7 antibody
Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody
Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody
RGD1561201 antibody
FOXO6
Forkhead box protein O6 antibody

Human,Mouse

WB,IF,ICC,FC

WB 1:1000
IF 1:100-1:400
ICC 1:1000
FC 1:1000

FOXO1, FKHR, FOXO1A, FOXO3, FKHRL1, FOXO3A, FOXO4, AFX, AFX1, MLLT7, FOXO6

q12778>swissprot: q12778 human;swissprot: o43524 human;swissprot: p98177 human;swissprot: a8myz6 human;swissprot: q9r1e0 mouse;swissprot: q9wvh4 mouse;swissprot: q9wvh3 mouse;swissprot: q70ky4 mouse

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Nucleus.

Cancer->Signal transduction->Nuclear signaling->Nuclear hormone receptors->Coactivators and repressors;Cancer->Signal transduction->Other;Epigenetics and Nuclear Signaling->Nuclear Signaling Pathways->Nuclear Receptors->Co-activators/co-repressors

Jurkat treated with 100nM Calyculin A for 40 minutes cell lysate, NIH/3T3 starved for 24 hours then add 100nM Calyculin A for 30 minutes cell lysate, Jurkat cells treated with 100nM Calyculin A for 40 minutes.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.