Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. There are three distinct sub-types of Smads: receptor-regulated Smads (R-Smads), common partner Smads (Co-Smads), and inhibitory Smads (I-Smads). The eight members of the Smad family are divided among these three groups. Trimers of two receptor-regulated SMADs and one co-SMAD act as transcription factors that regulate the expression of certain genes. The R-Smads consist of Smad1, Smad2, Smad3, Smad5 and Smad8/9, and are involved in direct signaling from the TGF-B receptor. R/Co-Smads are primarily located in the cytoplasm, but accumulate in the nucleus following TGF-β signaling, where they can bind to DNA and regulate transcription. However, I-Smads are predominantly found in the nucleus, where they can act as direct transcriptional regulators.

BSP-1 antibody
BSP1 antibody
HsMAD1 antibody
JV4-1 antibody
JV41 antibody
MAD homolog 1 antibody
MAD mothers against decapentaplegic homolog 1 antibody
Mad related protein 1 antibody
Mad-related protein 1 antibody
MADH1 antibody
MADR1 antibody
Mothers against decapentaplegic homolog 1 antibody
Mothers against DPP homolog 1 antibody
SMA- AND MAD-RELATED PROTEIN 1 antibody
SMAD 1 antibody
SMAD family member 1 antibody
SMAD mothers against DPP homolog 1 antibody
Smad1 antibody
SMAD1_HUMAN antibody
TGF beta signaling protein 1 antibody
Transforming growth factor-beta-signaling protein 1 antibody
DKFZp781C1895 antibody
DKFZp781O1323 antibody
Dwfc antibody
hSmad5 antibody
JV5 1 antibody
JV5-1 antibody
MAD homolog 5 antibody
MAD, mothers against decapentaplegic homolog 5 antibody
MADH 5 antibody
MADH5 antibody
Mothers against decapentaplegic homolog 5 antibody
mothers against decapentaplegic, drosophila, homolog of, 5 antibody
Mothers against DPP homolog 5 antibody
MusMLP antibody
SMA and MAD related protein 5 antibody
SMAD 5 antibody
SMAD family member 5 antibody
SMAD, mothers against DPP homolog 5 antibody
Smad5 antibody
SMAD5_HUMAN antibody
MAD homolog 9 antibody
Madh6 antibody
Mothers against decapentaplegic antibody
Mothers against decapentaplegic homolog 9 antibody
Mothers against DPP homolog 9 antibody
SMAD 9 antibody
SMAD family member 9 antibody
SMAD, mothers against DPP homolog 9 (Drosophila) antibody
SMAD8A antibody
SMAD8B antibody
Smad9 antibody
SMAD9_HUMAN antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000
IHC 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 52 kDa

SMAD1, BSP1, MADH1, MADR1, SMAD5, MADH5, SMAD9, MADH6, MADH9, SMAD8

q15797>swissprot: q15797 human;swissprot: q99717 human;swissprot: o15198 human;swissprot: p70340 mouse;swissprot: p97454 mouse;swissprot: q9jiw5 mouse;swissprot: o54835 rat;swissprot: p97588 rat;swissprot: q9r1v3 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Nucleus, Mitochondrion.

Developmental Biology->Organogenesis->Skeletal development->Bone;Cancer->Cancer Metabolism->Response to hypoxia;Cancer->Signal transduction->Nuclear signaling->SMAD family;Cancer->Signal transduction->Other;Cancer->Growth factors->TGF;Signal Transduction->Cytoskeleton / ECM->Extracellular Matrix->Structures->Bone

HeLa treated with 10ng/mL BMP4 for 1 hour cell lysate, NIH/3T3 treated with 10ng/mL BMP4 for 1 hour cell lysate, human testis tissue, C6 treated with 10ng/mL BMP4 for 1 hour cell lysate, HeLa cells treated with 10ng/mL BMP4 for 1 hour, NIH/3T3 cells treated with 10ng/mL BMP4 for 1 hour.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.