Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression, ensuring the integrity and functionality of cellular machinery. These regulatory enzymes play a crucial role in the regulation of eukaryotic cell cycle and transcription, as well as DNA repair, metabolism, and epigenetic regulation, in response to several extracellular and intracellular signals. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. The catalytic activities of CDKs are regulated by interactions with CDK inhibitors (CKIs) and regulatory subunits known as cyclins. Cyclins have no enzymatic activity themselves, but they become active once they bind to CDKs. Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with lysine (K) or arginine (R). This motif ensures CDKs accurately target and modify proteins, crucial for regulating cell cycle and other functions. Deregulation of the CDK activity is linked to various pathologies, including cancer, neurodegenerative diseases, and stroke.

Cdc 2 antibody
Cdc2 antibody
CDC28A antibody
CDK 1 antibody
CDK1 antibody
CDK1_HUMAN antibody
CDKN1 antibody
CELL CYCLE CONTROLLER CDC2 antibody
Cell division control protein 2 antibody
Cell division control protein 2 homolog antibody
Cell division cycle 2 G1 to S and G2 to M antibody
Cell division protein kinase 1 antibody
Cell Divsion Cycle 2 Protein antibody
Cyclin Dependent Kinase 1 antibody
Cyclin-dependent kinase 1 antibody
DKFZp686L20222 antibody
MGC111195 antibody
p34 Cdk1 antibody
p34 protein kinase antibody
P34CDC2 antibody
Cdc2 related protein kinase antibody
cdc2-related protein kinase antibody
CDC28 antibody
CDC2A antibody
Cdk 2 antibody
CDK2 antibody
CDK2_HUMAN antibody
CDKN2 antibody
Cell devision kinase 2 antibody
Cell division protein kinase 2 antibody
Cyclin dependent kinase 2 antibody
cyclin dependent kinase 2-alpha antibody
Cyclin-dependent kinase 2 antibody
kinase Cdc2 antibody
MPF antibody
p33 protein kinase antibody
p33(CDK2) antibody

Human

WB,Dot Blot

WB 1:1000
Dot Blot 1:1000

Predicted band size: 34 kDa

CDK1, CDC2, CDC28A, CDKN1, P34CDC2, CDK2, CDKN2

p24941>swissprot: p24941 human;swissprot: p06493 human

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Nucleus, Cytoplasm, Mitochondrion.

Cell Biology->Cell Cycle->Kinases/Phosphatases->Cdks;Cancer->Cell cycle->Kinases/phosphatases->Cdks;Epigenetics and Nuclear Signaling->Cell cycle->Kinases/Phosphatases->Cdks

HeLa treated with 100ng/mL Nocodazole for 18 hours cell lysate.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.