CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions. When embedded in the cell membrane, the membrane topology of prominin-1 is such that the N-terminus extends into the extracellular space and the C-terminus resides in the intracellular compartment. The protein consists of five transmembrane segments, with the first and second segments and the third and fourth segments connected by intracellular loops while the second and third as well as fourth and fifth transmembrane segments are connected by extracellular loops. CD133 is the most commonly used marker for isolation of cancer stem cell (CSC) population from different tumors, mainly from various gliomas and carcinomas. CD133+ melanoma cells are considered a subpopulation of CSC and play a critical role in recurrence. Moreover, CD133+ melanoma cells are immunogenic and can be used as an antimelanoma vaccination. In mice the vaccination with CD133+ melanoma cells mediated strong tumor activity that resulted in the eradication of parental melanoma cells. In addition, it has also been shown that CD133+ melanoma cells preferentially express the RNA helicase DDX3X . As DDX3X also is an immunogenic protein, the same melanoma vaccination strategy can be employed to give therapeutic antitumor immunity in mice.

AC133 antibody
Antigen AC133 antibody
CD133 antibody
CORD12 antibody
Hematopoietic stem cell antigen antibody
hProminin antibody
MCDR2 antibody
MSTP061 antibody
OTTHUMP00000217744 antibody
OTTHUMP00000217745 antibody
OTTHUMP00000217746 antibody
PROM1 antibody
PROM1_HUMAN antibody
Prominin I antibody
Prominin like 1 antibody
Prominin like protein 1 precursor antibody
Prominin mouse like 1 antibody
Prominin-1 antibody
Prominin-like protein 1 antibody
Prominin1 antibody
PROML1 antibody
RP41 antibody
STGD4 antibody

Mouse

WB,IHC,IF,ICC

WB 1:1000
IHC 1:200
IF 1:100
ICC 1:100-1:400

Predicted band size: 97 kDa

PROM1, PROML1, MSTP061

o54990>swissprot: o54990 mouse

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Endoplasmic reticulum. Plasma membrane. Cell projection.

Neuroscience

Mouse kidney tissue lysate, mouse colon tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.