p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene. The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. In addition to the full-length protein, the human TP53 gene encodes at least 12 protein isoforms.

Antigen NY-CO-13 antibody
BCC7 antibody
Cellular tumor antigen p53 antibody
FLJ92943 antibody
LFS1 antibody
Mutant tumor protein 53 antibody
p53 antibody
p53 tumor suppressor antibody
P53_HUMAN antibody
Phosphoprotein p53 antibody
Tp53 antibody
Transformation related protein 53 antibody
TRP53 antibody
tumor antigen p55 antibody
Tumor protein 53 antibody
Tumor protein p53 antibody
Tumor suppressor p53 antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:1000
IHC 1:200
IF 1:100-1:400
ICC 1:100

Predicted band size: 53 kDa

TP53, P53

p04637>swissprot: p04637 human;swissprot: p02340 mouse;swissprot: p10361 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, cytoskeleton, microtubule organizing center, centrosome.

Cell Biology->Cell Cycle->Cell Cycle Inhibitors->p53;Cell Biology->Apoptosis->Intracellular->p53 Pathway;Cancer->Cell cycle->Cell cycle inhibitors->p53 pathway;Epigenetics and Nuclear Signaling->Transcription->Cancer susceptibility->Tumor Suppressors;Epigenetics and Nuclear Signaling->Cell cycle->Cell Cycle Inhibitors->p53;Epigenetics and Nuclear Signaling->Chromatin Binding Proteins->DNA / RNA binding;Epigenetics and Nuclear Signaling->ChIP assays->ChIP kits

HT-29 cell lysate, HT-29 treated with 100ng/mL Nocodazole for 18 hours cell lysate, HT-29 cells treated with 100ng/mL Nocodazole for 18 hours, mouse liver tissue, human breast cancer tissue, human colon cancer tissue, human colon tissue, rat liver tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.