Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene and is part of the dynamin superfamily (DSP) family of proteins. Mitochondria routinely undergo fission and fusion events that maintain a dynamic reticular network. Drp1 is a fundamental component of mitochondrial fission. Indeed, Drp1 deficient neurons have large, strongly interconnected mitochondria due to dysfunctional fission machinery. Fission helps facilitate mitophagy, which is the breakdown and recycling of damaged mitochondria. Dysfunction in the DRP activity may result in mutated DNA or malfunctioning proteins diffusing throughout the mitochondrial system. In addition, fission results in fragmented mitochondria more capable of producing of reactive oxygen species, which can disrupt normal biochemical processes inside of cells. ROS can be formed from incomplete transfer of electrons through the electron transport chain. Furthermore, fission influences calcium flux within the cell, linking Drp1 to apoptosis and cancer.

DLP1 antibody
dnm1l antibody
DNM1L_HUMAN antibody
Dnm1p/Vps1p-like protein antibody
dnml1 antibody
DRP1 antibody
DVLP antibody
Dymple antibody
Dynamin 1 like antibody
Dynamin family member proline-rich carboxyl-terminal domain less antibody
Dynamin like protein antibody
Dynamin related protein 1 antibody
Dynamin-1-like protein antibody
Dynamin-like protein 4 antibody
Dynamin-like protein antibody
Dynamin-like protein IV antibody
Dynamin-related protein 1 antibody
DYNIV 11 antibody
EMPF antibody
EMPF1 antibody
FLJ41912 antibody
HdynIV antibody
VPS1 antibody

Human,Mouse,Rat

WB,IHC,IF,ICC,FC

WB 1:1000-1:5000
IHC 1:10000
IF 1:500-1:2000
ICC 1:100
FC 1:1000

Predicted band size: 82 kDa

DNM1L, DLP1, DRP1

o00429>swissprot: o00429 human;swissprot: q8k1m6 mouse;swissprot: o35303 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, cytosol, Golgi apparatus, Endomembrane system, Mitochondrion outer membrane, Peroxisome, Membrane, clathrin-coated pit, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.

Cell Biology->Apoptosis->Mitochondrial;Cancer->Cell Death->Apoptosis->Mitochondrial;Signal Transduction->Metabolism->Mitochondrial

HeLa cell lysate, HeLa treated with 100ng/mL Calyculin A for 30 minutes cell lysate, NIH/3T3 cell lysate, NIH/3T3 treated with 100ng/mL nocodazole for 18 hours cell lysate, HeLa, C2C12 cell lysate, PC-12 cell lysate, mouse brain tissue, Jurkat cell lysate, HEK-293 cell lysate, Human brain tissue lysate, Mouse brain tissue lysate, Mouse heart tissue lysate, Rat brain tissue lysate, Rat heart tissue lysate, rat brain tissue, PC-12.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.