TU22764

货号 规格 价格(¥)
TU22764S 50ul
TU22764M 100ul

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-Phospho-Rb (S795) Antibody

Datasheet

Background

The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.

Alternative Name

Exon 17 tumor GOS561 substitution mutation causes premature stop antibody
GOS563 exon 17 substitution mutation causes premature stop antibody
OSRC antibody
Osteosarcoma antibody
p105-Rb antibody
P105RB antibody
PP105 antibody
pp110 antibody
PPP1R130 antibody
pRb antibody
Prepro retinoblastoma associated protein antibody
Protein phosphatase 1 regulatory subunit 130 antibody
Rb antibody
RB transcriptional corepressor 1 antibody
RB_HUMAN antibody
RB1 antibody
RB1 gene antibody
Retinoblastoma 1 antibody
Retinoblastoma suspectibility protein antibody
Retinoblastoma-associated protein antibody

Reactivity

Human

Application

WB,IF,ICC

Recommended Dilution

WB 1:2000
IF 1:100-1:400
ICC 1:500

Application Image

Mol Weight

Predicted band size: 106 kDa

Gene Symbol

Retinoblastoma-associated protein
p105-Rb
p110-RB1
pRb (Rb)
pp110
RB1

Uniprot

p06400>swissprot: p06400 human

Uniprot link

Immunogen

Immunogen Range

Source

Rabbit

Clonality

Recombinant Rabbit monoclonal Antibody

Isotype

IgG

Specificity

Subcellular location

Nucleus.

Research Area

Positive control

HeLa treated with 100ng/mL Nocodazole for 18 hours cell lysate, HeLa cells treated with 100ng/mL Nocodazole for 18 hours, U-2 OS cell lysate, U-2 OS treated with 50ng/mL Nocodazole for 8 hours cell lysate.

Conjugation

Modification

Purification

Protein A affinity purified.

Formulation

Liquid

Concentration

1 mg/mL.

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

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华南经销商负责(广东,广西,福建,海南):
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徐经理:手机15618191473(微信同号)
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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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