Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene family. CBL gene, a part of the Cbl family, encodes the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia. Ubiquitination is the process of chemically attaching ubiquitin monomers to a protein, thereby targeting it for degradation. As this is a multi-step process, several different enzymes are involved, the final one being a member of the E3 family of ligases. Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's protein substrate - typically a receptor tyrosine kinase. The RING-finger domain mediates this transfer, however like other E3 ligases of the RING type no intermediate covalent bond is formed between ubiquitin and the RING-finger domain. The stepwise attachment of ubiquitin to the substrate receptor tyrosine kinase can lead to its removal from the plasma membrane and subsequent trafficking to the lysosome for degradation.

4732447J05Rik antibody
C CBL antibody
Cas Br M (murine) ecotropic retroviral transforming sequence antibody
Casitas B lineage lymphoma proto oncogene antibody
Casitas B-lineage lymphoma proto-oncogene antibody
CBL 2 antibody
cbl antibody
CBL_HUMAN antibody
CBL2 antibody
E3 ubiquitin protein ligase CBL antibody
E3 ubiquitin-protein ligase CBL antibody
Oncogene CBL2 antibody
Proto oncogene c CBL antibody
Proto-oncogene c-CBL antibody
RGD1561386 antibody
RING finger protein 55 antibody
RNF55 antibody
Signal transduction protein CBL antibody

Human

WB

WB 1:1000

Predicted band size: 100 kDa

CBL, CBL2, RNF55

p22681>swissprot: p22681 human

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Cell membrane, Cell projection, cilium, Golgi apparatus.

Cell Biology->Proteolysis / Ubiquitin->Proteasome / Ubiquitin->Ubiquitin E3 Enzymes->RING Finger E3 Ligase;Cancer->Signal transduction->Nuclear signaling->Nuclear hormone receptors->Coactivators and repressors;Cancer->Signal transduction->Other;Signal Transduction->Adapters->Cytoplasmic;Epigenetics and Nuclear Signaling->Transcription->Cancer susceptibility->Proto-oncogenes;Epigenetics and Nuclear Signaling->Nuclear Signaling Pathways->Nuclear Receptors->Co-activators/co-repressors;Epigenetics and Nuclear Signaling->Cell cycle->Apoptosis->Nuclear;Epigenetics and Nuclear Signaling->Chromatin Modifying Enzymes->Acetylation->HAT

A549 starved for 2 hours then add 1μM sodium orthovanadate for 1 hour cell lysate, HeLa treated with 1mM sodium orthovanadate for 30 minutes cell lysate.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.