Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.

ACAC antibody
ACACA antibody
ACACA_HUMAN antibody
ACACB antibody
ACC alpha antibody
ACC antibody
ACC beta antibody
ACC-alpha antibody
ACC1 antibody
ACC2 antibody
ACCA antibody
ACCB antibody
Acetyl CoA carboxylase 1 antibody
Acetyl CoA carboxylase 2 antibody
Acetyl CoA carboxylase alpha antibody
Acetyl CoA carboxylase beta antibody
Acetyl Coenzyme A carboxylase alpha antibody
Acetyl Coenzyme A carboxylase beta antibody
Biotin carboxylase antibody
COA1 antibody
COA2 antibody
HACC275 antibody
OTTHUMP00000164069 antibody
OTTHUMP00000164070 antibody
OTTHUMP00000164076 antibody
OTTHUMP00000240532 antibody

Human,Mouse,Rat

WB,IHC,IF,ICC

WB 1:2000
IHC 1:200
IF 1:100-1:400
ICC 1:50

Predicted band size: 266 kDa

Acaca, Acac, Gm738

q13085>swissprot: q13085 human;swissprot: q5swu9 mouse;swissprot: p11497 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, cytosol.

Cancer->Cancer Metabolism->Metabolic signaling pathway->Metabolism of lipids and lipoproteins;Cancer->Cancer Metabolism->Metabolic signaling pathway->Integration of energy metabolism;Signal Transduction->Metabolism->Lipid metabolism;Signal Transduction->Metabolism->Mitochondrial;Cardiovascular->Lipids / Lipoproteins->Fatty Acids->Synthesis;Cardiovascular->Lipids / Lipoproteins->Adipose Related->Acrp

SH-SY5Y cell lysate, SH-SY5Y treated with 200nM Calyculin A and 1μM Okadaic Acid for 1 hour cell lysate, RAW264.7 cell lysate, RAW264.7 treated with 200nM Calyculin A and 1μM Okadaic Acid for 1 hour cell lysate, C6 cell lysate, C6 treated with 100nM Calyculin A for 30 minutes cell lysate, PC-12, mouse liver tissue, rat liver tissue.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.