Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.

18 kDa phosphoprotein antibody
CFL 1 antibody
CFL antibody
CFL1 antibody
COF1_HUMAN antibody
Cofilin 1 antibody
Cofilin 1 non muscle antibody
Cofilin antibody
Cofilin non muscle isoform antibody
Cofilin-1 antibody
epididymis secretory protein Li 15 antibody
HEL-S-15 antibody
non-muscle isoform antibody
p18 antibody

Human,Rat,Monkey

WB

WB 1:2000

Predicted band size: 19 kDa

Cofilin-1
18 kDa phosphoprotein (p18)
Cofilin, non-muscle isoform
CFL1
CFL

p23528>swissprot: p23528 human;swissprot: p45592 rat

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Nucleus matrix, Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, lamellipodium membrane, lamellipodium, growth cone, axon.

Cancer->Invasion/microenvironment->ECM->Cell adhesion->Other;Cancer->Invasion/microenvironment->Angiogenesis->ECM enzymes->Cathespins;Cancer->Cancer Biomarker->Tumor antigens;Signal Transduction->Cytoskeleton / ECM->Cytoskeleton->Microfilaments->Actin etc->Actin Binding Proteins;Signal Transduction->Cytoskeleton / ECM->Cytoskeleton->Microfilaments->Actin etc->Actin;Cardiovascular->Heart->Contractility;Cardiovascular->Vasculature->Smooth muscle cell (SMC)->Cytoskeleton

COS-1 cell lysate, C6 cell lysate, Jurkat cell lysate, MCF7 cell lysate, A431 cell lysate.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.