Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity).

ACOD1 antibody
Aconitate decarboxylase 1 antibody
Aconitate decarboxylase antibody
CAD antibody
Cis aconitate decarboxylase antibody
Immune responsive gene 1 protein homolog antibody
Immune-responsive gene 1 protein homolog antibody
Immunoresponsive 1 homolog (mouse) antibody
Irg1 antibody
IRG1_HUMAN antibody
OC116 antibody
OPTB1 antibody
TCTIRC7 antibody

Mouse

WB,IF,ICC

WB 1:1000
IF 1:100-1:400
ICC 1:100

Predicted band size: 54 kDa

Acod1, Irg1

p54987>swissprot: p54987 mouse

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Mitochondrion.

RAW264.7 treated with 0.1μg/mL LPS for 6 hours cell lysate, J774A.1 treated with 1μg/mL LPS for 24 hours cell lysate, mBMMC treated with 0.1μg/mL LPS and 10ng/mL IFN-gamma for 24 hours cell lysate, mBMSC treated with 40ng/mL MCSF for 7 days then add 100ng/mL LPS for 48 hours cell lysate, RAW264.7 cells treated with 0.1μg/mL LPS for 6 hours.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.