In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. In biochemistry, the PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ for activation. Thus, conventional and novel PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and ι / λ isoforms) require neither Ca2+ nor diacylglycerol for activation.

KPCA_HUMAN antibody
PKC alpha antibody
PKC beta antibody
PKC delta antibody
PKC epsilon antibody
PKC gamma antibody
PKC zeta antibody
PKC-A antibody
PKC-alpha antibody
PKC2 antibody
PKCA antibody
PKCB antibody
PKCD antibody
PKCE antibody
PKCG antibody
PRKCA antibody
PRKCB antibody
PRKCB1 antibody
PRKCB2 antibody
PRKCD antibody
PRKCE antibody
PRKCG antibody
PRKCZ antibody
Protein kinase C alpha antibody
Protein kinase C alpha type antibody
Protein kinase C antibody
Protein kinase C beta antibody
Protein kinase C delta antibody
Protein kinase C epsilon antibody
Protein kinase C gamma antibody
Protein kinase C zeta antibody

Human,Mouse,Rat

WB,IHC

WB 1:1000
IHC 1:200

Predicted band size: 84 kDa

Protein kinase C epsilon type
EC:2.7.11.13
nPKC-epsilon

p05129>swissprot: p05129 human;swissprot: p05771 human;swissprot: p17252 human;swissprot: q02156 human;swissprot: q05513 human;swissprot: q05655 human

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, cytoskeleton, Cell membrane, perinuclear region, Nucleus.

Signal Transduction->Protein Phosphorylation->Ser / Thr Kinases->PKC;Cardiovascular->Heart->Hypertrophy->Other;Epigenetics and Nuclear Signaling->Histones->H3->Methylated

HeLa cell lysate, HeLa treated with 200nM TPA for 30 minutes cell lysate, C2C12 cell lysate, C2C12 treated with 200nM TPA for 30 minutes cell lysate, C6 cell lysate, C6 treated with 200nM TPA for 10 minutes cell lysate.

Protein A affinity purified.

Liquid

1 mg/mL.

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.