Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Calcium dependent phospholipid binding protein antibody
CPLA 2 antibody
cPLA2 alpha antibody
cPLA2 antibody
Cytosolic phospholipase A2 antibody
Cytosolic phospholipase A2 group IVA antibody
Lysophospholipase antibody
MGC126350 antibody
PA24A_HUMAN antibody
Phosphatidylcholine 2 acylhydrolase antibody
Phosphatidylcholine 2-acylhydrolase antibody
Phospholipase A2 group 4 A antibody
Phospholipase A2 group IVA (cytosolic calcium dependent) antibody
Phospholipase A2 group IVA antibody
PhospholipaseA2 antibody
PLA2G4 antibody
pla2g4a antibody

Human,Mouse

WB,Dot Blot

WB 1:1000-1:2000
Dot Blot 1:1000

Predicted band size: 85 kDa

PLA2G4A, CPLA2, PLA2G4

p47712>swissprot: p47712 human;swissprot: p47713 mouse

Rabbit

Recombinant Rabbit monoclonal Antibody

IgG

Cytoplasm, Golgi apparatus membrane, Nucleus envelope.

Immunology->Innate Immunity->Macrophage / Inflamm;Cardiovascular->Atherosclerosis->Vascular Inflammation->Inflammatory mediators;Cardiovascular->Atherosclerosis->Lipoprotein metabolism

HeLa cell lysate, RAW264.7 cell lysates.

Protein A affinity purified.

Liquid

1 mg/mL.

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.