May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

TBC1D4 (phospho S588); p-TBC1D4 (phospho S588);
Acrg embryonic lethality (mouse) minimal region ortholog;
Acrg embryonic lethality minimal region ortholog;
Acrg embryonic lethality mouse minimal region ortholog;
Akt substrate of 160 kDa;
AS 160;
AS160;
BUB2;
CDC16;
DKFZp779C0666;
KIAA0603;
OTTHUMP00000040818;
TBC (Tre 2 BUB2 CDC16) domain containing protein;
TBC Tre 2 BUB2 CDC16 domain containing protein;
TBC1 D4;
TBC1 domain family member 4;
Tbc1d4;
TBCD4_HUMAN;
Tre-2.

Human,Rat,Cow,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

60/147kD

9882

O60343

https://www.uniprot.org/uniprotkb/O60343

Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.

KLH conjugated synthesised phosphopeptide derived from human TBC1D4 around the phosphorylation site of Ser588

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.