Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1
Human, Mouse, Rat
Pig, Bovine, Horse, Sheep, Rabbit, Dog
WB,IHC
WB 1:500-1:2000IHC 1:50-1:500
226kD; 227kDa(Calculated).
MDC1 KIAA0170 NFBD1
q14676
Rabbit
Polyclonal
Rabbit IgG
MDC1 Antibody detects endogenous levels of total MDC1.
Nucleus localization
DNA damage #DNA excision
PBS,pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at -20 °C. Stable for 12 months from date of receipt.
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