Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

Leukolysin;
Leukolysin;
matrix metallopeptidase 25;
matrix metallopeptidase like 1;
matrix metalloproteinase 20;
Matrix Metalloproteinase 25;
Matrix Metalloproteinase 25;
Matrix metalloproteinase 25 precursor;
Membrane type 6 Matrix Metalloproteinase;
Membrane type Matrix Metalloproteinase 6;
MMP 25;
MMP20;
MMP20A;
MMP20A;
MMPL1;
MT MMP 6;
MT6 MMP.

Human,Mouse,Rat,Dog,Pig,Cow,Horse

WB

WB 1:500-2000

65kD

64386

Q9NPA2

https://www.uniprot.org/uniprotkb/Q9NPA2

Cell Membrane; lipid-anchor; GPI-anchor.

Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.

KLH conjugated synthetic peptide derived from human MMP25

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.