TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

Activation inducible TNFR family receptor;
Activation-inducible TNFR family receptor;
AITR;
CD357;
GITR;
GITR D;
GITR-D;
GITRD;
Glucocorticoid induced TNFR related protein;
glucocorticoid-induced tnf receptor ligand;
glucocorticoid-induced tnf receptors ligand;
Glucocorticoid-induced TNFR-related protein;
TNF receptor superfamily activation inducible protein;
TNFRSF 18;
TNR18_HUMAN;
Tumor necrosis factor receptor superfamily member 18;
Tumor necrosis factor receptor superfamily member 18 precursor;

Human,Mouse,Rat

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

24kD

8784

O35714

https://www.uniprot.org/uniprotkb/O35714

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

KLH conjugated synthetic peptide derived from mouse TNFRSF18

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.