This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

MASP1/3; MASP-1; Complement factor MASP-3; Complement factor MASP3; Complement-activating component of Ra-reactive factor; CRARF; EC 3.4.21; Mannan binding lectin serine protease 1; Mannose binding lectin associated serine protease 1; Mannose binding protein associated serine protease; Mannose-binding lectin-associated serine protease 1; Mannose-binding lectin-associated serine protease-1; MASP; PRSS 5; Ra reactive factor serine protease p100; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; MASP1_HUMAN.
Mannan-binding lectin serine protease 1; Mannan-binding lectin serine protease 1 heavy chain; MASP1_HUMAN.

Rat,Human,Mouse,Dog,Pig,Cow,Rabbit

WB

WB 1:500-2000

49/77kD

5648

P48740

https://www.uniprot.org/uniprotkb/P48740

Secreted.

Protein of the plasma which is primarily expressed by liver.

KLH conjugated synthetic peptide derived from human MASP

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.