LGALS3BP is a ligand of galectin 3, and has been suggested to influence tumor proliferation and metastasis formation. Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. LGALS3BP also known as Mac 2 BP,and as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin 1, galectin 3 and galectin 7. High expression levels of this molecule are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy. The mechanisms underlying the prognostic significance of 90K and galectins in cancer are far from being understood, although they may be related to the ability of these proteins to interact and, to some extent, modulate cell cell and cell matrix adhesion and apoptosis.

Mac 2 binding protein; MAC2BP; Tumor associated antigen 90K; 90K; 90K MAC 2 BP; Basement membrane autoantigen p105; Galectin 3 binding protein; L3 antigen; Lectin galactoside binding soluble 3 binding protein; M2BP; Mac 2 BP; Serum protein 90K; LG3BP_HUMAN.

Human,Mouse

WB,IHC,IF,ICC,ELISA

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400
ELISA 1:5000-1:20000

63kD

3959

Q08380

https://www.uniprot.org/uniprotkb/Q08380

Secreted. Secreted, extracellular space, extracellular matrix.

Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.

KLH conjugated synthetic peptide derived from human LGALS3BP

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.