The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.

CBP;
Csk Binding Protein;
Csk-binding protein;
FLJ37858;
MGC138364;
PAG 1;
PAG;
PAG1;
PAG1_HUMAN;
Phosphoprotein associated with glycosphingolipid enriched microdomains 1;
Phosphoprotein associated with glycosphingolipid enriched microdomains;
Phosphoprotein associated with glycosphingolipid microdomains 1;
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1;
Protein Associated with Glycosphingolipid Enriched Microdomains;
Transmembrane adapter protein PAG;
Transmembrane phosphoprotein Cbp.

Mouse,Rat,Human,Dog,Horse,Rabbit

WB,IHC,IF,ICC

WB 1:500-2000
IHC 1:100-500
IF 1:100-1:400
ICC 1:100-1:400

47kD

55824

Q9NWQ8

https://www.uniprot.org/uniprotkb/Q9NWQ8

Cell membrane. Present in lipid rafts.

Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).

KLH conjugated synthetic peptide derived from human PAG1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.