Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines. SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

pp55;
SCAP 1;
SCAP1;
SKAP 1;
SKAP 55;
SKAP-55;
Skap1;
SKAP1_HUMAN;
SKAP55 adaptor protein;
SRC family associated phosphoprotein 1;
Src family-associated phosphoprotein 1;
Src kinase associated phosphoprotein 1;
SRC kinase associated phosphoprotein 55 kD;
Src kinase associated phosphoprotein of 55 kDa;
Src kinase-associated phosphoprotein 1;
Src kinase-associated phosphoprotein of 55 kDa.

Rat,Human,Mouse,Dog,Pig,Horse,Rabbit

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

41kD

8631

Q86WV1

https://www.uniprot.org/uniprotkb/Q86WV1

Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).

KLH conjugated synthetic peptide derived from human SKAP55

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.