PRELP (proline/arginine-rich end leucine-rich repeat protein), also known as Prolargin, MST161, SLRR2A or MSTP161, is a 382 amino acid secreted protein that localizes to the extracellular matrix. Belonging to the Class II subfamily of the small leucine-rich proteoglycan (SLRP) family, PRELP contains twelve LRR (leucine-rich) repeats, which are motifs consisting of 20-29 residues that are present in numerous proteins with diverse functions and provide versatile structural framework for the formation of protein-protein interactions. Highly expressed in cartilage, basement membranes and developing bone, PRELP is considered a glycosaminoglycan (GAG)- and collagen-binding anchor protein that associates with the basement membrane heparan sulfate proteoglycan perlecan. PRELP acts as a linker between the extracellular matrix and the cell surface of proteoglycans and may be partially responsible for Hutchinson-Gilford progeria (HGP), an extremely rare genetic disorder that causes premature, rapid aging shortly after birth.

55 kDa leucine rich repeat protein of articular cartilage;
MST161;
MSTP161;
Prelp;
PRELP_HUMAN;
Prolargin;
Prolargin proteoglycan;
Proline arginine rich end leucine rich repeat protein;
Proline-arginine-rich end leucine-rich repeat protein;
Proline/arginine rich end leucine rich repeat protein;
SLRR2A.

Human,Mouse,Rat,Cow,Horse,Rabbit

ELISA

ELISA 1:5000-10000

42kD

5549

P51888

https://www.uniprot.org/uniprotkb/P51888

Secreted > extracellular space > extracellular matrix.

Connective tissue.

KLH conjugated synthetic peptide derived from human PRELP

Rabbit

Polyclonal

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.