This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008]

Acute myeloid leukemia 1;
Acute myeloid leukemia 1 protein;
alpha subunit core binding factor;
AML 1;
AML1;
AML1 EVI 1;
AML1 EVI 1 fusion protein;
Aml1 oncogene;
AMLCR 1;
AMLCR1;
CBF alpha 2;
CBF-alpha-2;
CBFA 2;
CBFA2;
Core binding factor alpha 2 subunit;
Core binding factor runt domain alpha subunit 2;
Core-binding factor subunit alpha-2;
EVI 1;
EVI1;
HGNC;
Oncogene AML 1;
Oncogene AML-1;
OTTHUMP00000108696;
OTTHUMP00000108697;
OTTHUMP00000108699;
OTTHUMP00000108700;
OTTHUMP00000108702;
PEA2 alpha B;
PEA2-alpha B;
PEBP2 alpha B;
PEBP2-alpha B;
PEBP2A2;
PEBP2aB;
Polyomavirus enhancer binding protein 2 alpha B subunit;
Polyomavirus enhancer-binding protein 2 alpha B subunit;
Run1;
Runt related transcription factor 1;
Runt-related transcription factor 1;
RUNX 1;
Runx1;
RUNX1_HUMAN;
SL3 3 enhancer factor 1 alpha B subunit;
SL3-3 enhancer factor 1 alpha B subunit;
SL3/AKV core binding factor alpha B subunit;
SL3/AKV core-binding factor alpha B subunit.

Human,Mouse,Rat,Cow

WB

WB 1:500-2000

49kD

861

Q01196

https://www.uniprot.org/uniprotkb/Q01196

Nucleus.

Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.

KLH conjugated synthetic peptide derived from human RUNX1 + RUNX2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.