alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor that was able to “bait” proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to “trap” the proteinase and further inhibit its activity. Subsequently, alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGF beta) in serum is primarily bound to alpha-2M, which renders TGF∫ inactive. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimer's Disease (AD). Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is expressed in the epidermis and may play a role in keratinocyte differentiation.

A2ML 1;
Alpha 2 macroglobulin like 1;
Alpha 2 macroglobulin like protein 1;
C3 and PZP like alpha 2 macroglobulin domain containing protein 9;
CPAMD9;
DKFZp686C1729;
DKFZp686D2011;
DKFZp686G1812;
DKFZp686L1821;
DKFZp686O1010;
FLJ16045;
FLJ25179;
FLJ39129;
FLJ41597;
FLJ41598;
FLJ41607; A2ML1_HUMAN.

Human,Horse

ELISA

ELISA 1:5000-10000

159kD

144568

A8K2U0

https://www.uniprot.org/uniprotkb/A8K2U0

Secreted

In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.

KLH conjugated synthetic peptide derived from human A2ML1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.