This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]

DHRD;
Doyne honeycomb retinal degeneration;
DRAD;
EFEMP 1;
EFEMP1;
EGF containing fibulin like extracellular matrix protein 1;
EGF containing fibulin like extracellular matrix protein 1 precursor;
EGF-containing fibulin-like extracellular matrix protein 1;
Epidermal growth factor containing fibulin like extracellular matrix protein 1;
Extracellular protein S1 5;
Extracellular protein S1-5;
FBLN 3;
FBLN3;
FBLN3_HUMAN;
FBNL;
FIBL 3;
FIBL-3;
FIBL3;
Fibrillin like;
Fibrillin like protein;
Fibrillin-like protein;
FIBULIN 3;
Fibulin-3;
Fibulin3;
FLJ35535;
Heat shock 70 KD protein 1;
MGC111353;
MLVT;
MTLV;
S1 5;
T16 protein.

Mouse,Human,Rat

WB

WB 1:500-2000

53kD

2202

Q12805

https://www.uniprot.org/uniprotkb/Q12805

Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.

In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.

KLH conjugated synthetic peptide derived from human EFEMP1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.