The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]

Acetylneuraminyl hydrolase;
exo-alpha-sialidase;
G9 sialidase;
Lysosomal sialidase;
N acetyl alpha neuraminidase 1;
N-acetyl-alpha-neuraminidase 1;
NANH;
NEU;
NEU1;
NEUR1_HUMAN;
Neuraminidase 1;
Neuraminidase;
SIAL1;
sialidase 1 (lysosomal sialidase);
Sialidase 1;
Sialidase, lysosomal;
Sialidase-1.

Human,Rat,Cow

WB

WB 1:500-2000

45kD

4758

Q99519

https://www.uniprot.org/uniprotkb/Q99519

Lysosome membrane. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.

Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.

KLH conjugated synthetic peptide derived from human NEU1/Neuraminidase

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.