CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3 epsilon;
CD3e;
CD3e antigen epsilon polypeptide (TiT3 complex);
CD3E antigen epsilon polypeptide;
CD3E antigen, epsilon subunit;
CD3e molecule epsilon;
CD3e molecule, epsilon (CD3 TCR complex);
CD3e molecule, epsilon (CD3-TCR complex);
CD3E_PIG;
IMD18;
T cell antigen receptor complex epsilon subunit of T3;
T cell surface antigen T3/Leu 4 epsilon chain;
T cell surface glycoprotein CD3 epsilon chain;
T-cell surface antigen T3/Leu-4 epsilon chain;
T-cell surface glycoprotein CD3 epsilon chain;
T3E;
TCRE.

Mouse,Pig

WB

WB 1:500-2000

20kD

916

P07766

https://www.uniprot.org/uniprotkb/P07766

Membrane; Single-pass type I membrane protein.

KLH conjugated synthetic peptide derived from pig CD3

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.