DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regulators (1). CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex),which increases the accessibility of nucleosomal DNA in an ATP-dependent manner (2). Unlike other known chromatin remodelling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing (3). This conversion process occurs when CHRAC organizes randomly deposited histones into a regularly spaced array (4). In the presence of CHRAC, the nucleosomal ATPase ISWI catalyses several ATP-dependent transitions of chromatin structure (5).

CHARC1;
CHARC15;
CHRAC-1;
CHRAC-15;
Chrac1;
CHRAC15;
CHRC1_HUMAN;
Chromatin accessibility complex 1;
Chromatin accessibility complex 15 kDa protein;
Chromatin accessibility complex protein 1;
DNA polymerase epsilon subunit p15;
histone-fold protein CHRAC15;
HuCHRAC15;
YCL1.

Human,Mouse,Rat,Chicken,Cow,Sheep

WB

WB 1:500-2000

14kD

54108

Q9NRG0

https://www.uniprot.org/uniprotkb/Q9NRG0

Nucleus.

Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

KLH conjugated synthetic peptide derived from human CHRAC1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.