Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns, and they are required for accurate splice site recognition and the control of alternative splicing (1). Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20, and SF2/ASF (2). The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain, and they are essential for constitutive splicing and also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites (3,4). The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport (5). The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing-sites (6).

21 GARP;
21 glutamic acid rich protein;
21-GARP;
SH3 domain binding glutamic acid rich protein;
SH3BGR;
SH3BGR protein;
Serine/arginine-rich splicing factor 7;
SRSF7_HUMAN.

Rat,Human,Mouse,Chicken,Cow,Zebrafish

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

27kD

6432

Q16629

https://www.uniprot.org/uniprotkb/Q16629

Nuclear

Brain, liver, kidney and lung.

KLH conjugated synthetic peptide derived from human SRSF7

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.