SLM5 (mitochondrial asparaginyl-tRNA synthetase, Asparagine-tRNA ligase) is a mitochondrial protein encoded by the human gene NARS2. AsnRS belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl tRNA synthetases (aaRS) are enzymes that catalyze the esterification of a specific amino acid or its precursor to its compatible cognate tRNA to form an aminoacyl-tRNA. The synthetase first binds ATP and the corresponding amino acid or its precursor to form an aminoacyl-adenylate and release inorganic pyrophosphate (PPi). The adenylate-aaRS complex then binds the appropriate tRNA molecule, and the amino acid is transferred from the aa-AMP to either the 2'- or 3'-OH of the last tRNA base (A76) at the 3'-end. Some synthetases also mediate a proofreading reaction to ensure high fidelity of tRNA charging; if the tRNA is found to be improperly charged, the aminoacyl-tRNA bond is hydrolyzed. SLM5 acts to attach asparagine residues to its cognate tRNA.

AI875199;
AsnRS;
Asparagine tRNA ligase 2;
Asparagine tRNA ligase 2 mitochondrial;
Asparagine tRNA ligase;
Asparaginyl tRNA synthetase 2;
Asparaginyl tRNA synthetase 2 mitochondrial;
FLJ23441;
MGC125113;
MGC41336;
NARS 2;
Probable asparaginyl tRNA synthetase;
Probable asparaginyl tRNA synthetase mitochondrial;
RGD1305145;
SLM5.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep

IHC,IF,ICC

IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

52kD

79731

Q96I59

https://www.uniprot.org/uniprotkb/Q96I59

Mitochondrion matrix.

KLH conjugated synthetic peptide derived from human NARS2

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.