Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Cubilin co-localizes with and binds to Megalin, a 600kDa member of the LDL receptor family that is required for the internalization of cubilin-bound ligands, such as vitamin B12, apolipoprotein A1 and Albumin. Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12.

460 kDa receptor; cubilin (intrinsic factor-cobalamin receptor); Cubilin precursor; CUBN; IFCR; Intestinal intrinsic factor receptor; intrinsic factor B12-receptor; intrinsic factor-cobalamin receptor; intrinsic factor-vitamin B12 receptor; megaloblastic anemia 1; MGA1.

Human

WB,IHC,IF,ICC

WB 1:1000-1:2000
IHC 1:100-500
IF 1:100-500
ICC 1:100-1:400

395kD

8029

O60494

https://www.uniprot.org/uniprotkb/O60494

Endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.

Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.

Recombinant human Cubilin protein

Rabbit

Recombinant

IgG

affinity purified by Protein A

Liquid

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.