Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.

hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; KV-BETA-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1.

Human,Rat,Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep

WB

WB 1:500-2000

47kD

7881

Q14722

https://www.uniprot.org/uniprotkb/Q14722

Cytoplasm.

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.

KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.