The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Cofactor required for Sp1 transcriptional activation subunit 8 (34kD);
Cofactor required for Sp1 transcriptional activation subunit 8 34kDa;
Cofactor required for Sp1 transcriptional activation subunit 8;
CRAP 34;
CRAP34;
CRSP 34;
CRSP 8;
CRSP complex subunit 8;
CRSP34;
MED 27;
Med27;
MED27_HUMAN;
Mediator complex subunit 27;
Mediator of RNA polymerase II transcription subunit 27;
MGC11274;
P37 TRAP/SMCC/PC2 subunit;
Transcriptional coactivator CRSP34;
TRAP 37;
TRAP37.

Mouse,Human,Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep

WB

WB 1:500-2000

35kD

9442

Q6P2C8

https://www.uniprot.org/uniprotkb/Q6P2C8

Nucleus.

KLH conjugated synthetic peptide derived from human CRSP8

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.