Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

DR1 associated corepressor;
DR1 associated protein 1 (negative cofactor 2 alpha);
DR1 associated protein 1;
DR1 associated protein1;
Dr1-associated corepressor;
Dr1-associated protein 1;
DRAP 1;
DRAP1;
NC 2 alpha;
NC 2alpha;
NC2 alpha;
NC2-alpha;
NC2A_HUMAN;
Negative co-factor 2-alpha;
Negative cofactor 2 alpha;
Negative cofactor 2alpha.

Mouse,Human,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep

WB

WB 1:500-2000

22kD

10589

Q14919

https://www.uniprot.org/uniprotkb/Q14919

Nucleus

Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.

KLH conjugated synthetic peptide derived from human NC2 alpha

Rabbit

Polyclonal

IgG

affinity purified by Protein A

Liquid

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.